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Xiaodong Wang (biochemist)
Xiaodong Wang (, born 1963) is a Chinese-born American biochemist best known for his work with cytochrome c. His laboratory developed an in-vitro assay for the activation of the apoptosis related proteinase Caspase-3. This allowed the biochemical purification of a complex of Cytochrome c, Caspase-9 and the Apoptotic Protease Activating factor-1 (APAF1). These components are essential for forming a ternary complex called the apoptosome that activates Caspase-3 downstream of the intracellular or mitochondrial pathway of apoptosis.〔
(【引用サイトリンク】title=Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.Cell. 1997 Aug 8;90(3):405-13. )〕
He was awarded the 2006 Shaw Prize in Life Science and Medicine.
Wang is a member of United States National Academy of Sciences and the Howard Hughes Medical Institute. Currently he is a professor at National Institute of Biological Sciences, Beijing.〔(Xiaodong Wang, Ph.D. Lab Research Profile )〕
==Honors & awards==
* 2007, Richard Lounsbery Award, from the National Academy of Sciences, USA
* 2006, Shaw Prize, from the Shaw Foundation
* 2004, NAS Award in Molecular Biology
* 2002, Hackerman Award, from the Welch Foundation
* 2001, Paul Marks Prize, from the Memorial Sloan-Kettering Cancer Center
* 2000, Eli Lilly Award in Biological Chemistry, from American Chemical Society
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